Insights into the In-vivo Antiplasmodial Activity of Trisdimethylamino Pyrimidine Derivative in Plasmodium berghei: Infected Mouse Model

Aims: To evaluate the antiplasmodial activity of a trisdimethylamino pyrimidine derivative synthesized by indirect methylation p-nitrophenylacetic acid via substituted amine or amide against Plasmodium berghei NK65 strain in an vivo berghei-Infected mouse model.
 Methodology: berghei-parasitized suppressive model Albino mice was adopted for evaluation. The schizontocidal compound evaluated 4-day test. All treatments (test sample, standard control and blank) were administered intraperitoneally to mice. Parameters such as rectal temperature, packed cell volume, survival time parasitemia measured.
 Results: 10, 20 40 mg/kg doses 2, 4, 6-trisdimethylamino-5-(4´-nitrophenyl) elicited statistically significant reduction (p < 0.01) level treated dose caused 97.19% suppression mean 22 days compared with 97.64% 24 respectively group (artemether-lumefantrine combination, 5 mg/kg). restored volume baseline (~39.8%). A dose-dependent decrease temperature observed all treatment groups. However, only 10 control.
 Conclusion: strong has further provided insights into potential lead discovery antimalarial agents.